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EZ2 Automated DNA and RNA Extraction System – Product Overview

January 22, 2026 by
Lieven Gentaur

Product Details

The EZ2 automated nucleic acid extraction system is a compact benchtop instrument designed to streamline DNA and RNA purification using prefilled, cartridge-based workflows. The system is capable of processing up to 24 samples simultaneously, making it ideal for research laboratories that require both efficiency and reproducibility.

EZ2 automation covers several workflow steps that were traditionally manual, including:

  • Automatic piercing of sealed reagent cartridges

  • Controlled heating for incubation and lysis steps

  • Automated pipetting of magnetic beads, buffers, and enzymes

Thanks to its intuitive touchscreen interface, the EZ2 system is easy to operate, even for new or minimally trained laboratory staff. Built-in remote connectivity also allows users to monitor extraction runs and manage the instrument outside the laboratory, improving workflow flexibility and lab coordination.

EZ2 extraction systems are designed to handle a wide variety of biological samples, including:

  • FFPE samples

  • Liquid biopsy samples

  • Trace and low-input samples

  • Cultured cells

  • Tissue samples

  • Whole blood and other liquid samples

Each EZ2 kit runs on preprogrammed protocols, ensuring consistent extraction conditions across different sample types. This flexibility allows research laboratories to meet changing experimental needs without modifying workflows or equipment.


High Throughput and Reproducibility

The EZ2 automated platform significantly reduces manual handling by replacing traditional pipetting steps with prefilled reagent cartridges. This approach minimizes user-dependent variability and enhances reproducibility between runs.

Key performance benefits include:

  • Processing up to 24 samples per run

  • Reduced hands-on time

  • Consistent nucleic acid yield and purity

  • Lower risk of contamination

EZ2 automation helps laboratories increase throughput while maintaining high analytical quality.

The EZ2 system supports remote instrument monitoring, allowing users to:

  • Track run progress in real time

  • Receive notifications when runs are completed

  • Manage workflows from tablets, smartphones, or desktop computers

This feature is particularly useful for busy laboratories running multiple instruments or coordinating work across different shifts.

EZ2 Extraction Principle Explained


How the EZ2 System Works

The EZ2 automated nucleic acid extraction workflow is based on in-tip magnetic bead technology and follows these steps:

  1. Cartridge Piercing

    Sealed, prefilled reagent cartridges are automatically opened using an integrated piercing mechanism.

  2. Automated Liquid Handling

    A 24-channel pipettor head aspirates and dispenses samples and reagents with precision.

  3. Temperature-Controlled Incubation

    An onboard heating system regulates liquid temperature during critical steps such as lysis.

  4. Magnetic Bead Purification

    DNA or RNA binds to magnetic beads, followed by automated washing and elution steps performed inside the pipette tips.

This fully automated process ensures high purity nucleic acids suitable for sensitive downstream applications.

EZ2 Applications in Molecular Research


Purified DNA and RNA obtained using EZ2 systems are compatible with a wide range of downstream techniques, including:

  • PCR and qPCR

  • Digital PCR (dPCR)

  • Next-generation sequencing (NGS)

  • Gene expression analysis

  • Genomic and transcriptomic studies

EZ2 automation supports reliable molecular analysis by delivering consistent input material for these workflows.



Conclusion

The EZ2 automated nucleic acid extraction system provides research laboratories with a powerful combination of throughput, reproducibility, and ease of use. By automating complex pretreatment steps and supporting a wide range of sample types, EZ2 platforms help labs improve efficiency while maintaining high-quality DNA and RNA purification.

Frequently Asked Questions

EZ2 is used for automated DNA and RNA extraction from various biological samples using cartridge-based workflows.

EZ2 systems can process up to 24 samples at the same time, depending on the protocol.

Yes, EZ2 systems allow users to monitor extraction runs remotely and manage the instrument outside the laboratory.

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